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Benzodiazepine Receptors Benzodiazepine receptors - highly expressed in the liver - and abnormal hepatic metabolism have been suggested to participate in several neuropsychiatric disorders including autism (Tsuchiya et al, 2000). In 100% of autistic children liver dysfunction was seen (Edelson,1998). Benzodiazepine receptors are modulated by thyroid status. (Medina, 1985). see also: GABA Prolactin TRH Puberty ================================ ====== Edelson SB, Cantor DS - "Autism: xenobiotic influences" Toxicol Ind Health 14(4):553-63 (1998) http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9664646&form=6&db=m&Dopt=r Lacau de Mengido IM, Diaz-Torga GS, Libertun C - “Diazepam: endocrine effects and hypothalamic binding sites in the developing male and female rat” Life Sci 45(7):567-75 (1989) Medina JH, De Robertis E - "Benzodiazepine receptor and thyroid hormones: in vivo and in vitro modulation" J Neurochem 44(5):1340-4 (1985) http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2985750&form=6&db=m&Dopt=r Tsuchiya H, Hayashi T - "A possible link between beta -carboline metabolism and infantile autism" Med Hypotheses 55(3):215-7 (2000)
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