OPIOIDS

   Autistic children show elevated plasma and CSF levels of opioid peptides (see: Trottier, 1999).

   Bhargava (1988) has published results from rat experiments indicating that brain, mu-, delta- and kappa-opioid receptors are differentially altered in hypothyroidism. The binding of 3H-DAGO to membranes of amygdala, pons and medulla, striatum, midbrain and cortex  was greater in hypothyroid rats.

   Hypothyroid patients show increased sensitivity to opiates while
hyperthyroid patients are tolerant to opiates (Clur, 1985).

G q/11:  (Joshi et al, 1999; Cox et al, 2000)

see also: addiction

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Bhargava HN, Ramarao P, Gulati A - "Effect of methimazole-induced hypothyroidism on multiple opioid receptors in rat brain regions" Pharmacology 37(6):356-64 (1988) http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2854273&form=6&db=m&Dopt=r

Clur A  - "Iodothyronines and iodotyrosines as hypothetical receptors for catecholamines and opiates"Med Hypotheses 16(2):97-131 (1985) http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2985942&form=6&db=m&Dopt=r

Cox SL, Schelb V, Trendelenburg AU, Starke K - "Enhancement of noradrenaline release by angiotensin II and bradykinin in mouse atria: evidence for cross-talk between G(q/11) protein- and G(i/o) protein-coupled receptors" Br J Pharmacol 129(6):1095-102 (2000) http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10725257&form=6&db=m&Dopt=r

Joshi S, Lee JW, Wong YH- "Stimulation of phospholipase C by the cloned mu, delta and kappa opioid receptors via chimeric G alpha(q) mutants" Eur J Neurosci 11(2):383-8 (1999) http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10051738&form=6&db=m&Dopt=r

Trottier G, Srivastava L Walker CD, - "Etiology of infantile autism: a review of recent advances in genetic and neurobiological research" J Psychiatry Neurosci 24(2):103-115 (1999)] FULL TEXT: http://www.cma.ca/jpn/vol-24/issue-2/0103.htm