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Cell Death Programmed cell death, sometimes referred to as apoptosis, is an essential part of normal development, particularly in the nervous system. Excesses and deficits in neuronal numbers have been observed in autism (i.e. Margolis et al, 1994) It is well-established that the thyroid hormone system is involved in the control of programmed cell death (see: Labudova et al, 1999). The role of Gq/11 in apoptosis is - of course - also established (i.e. Dulin et al, 2000). ================================== Dulin NO, Pratt P, Tiruppathi C, Niu J, Voyno-Yasenetskaya T, Dunn MJ - “Regulator of G protein signaling RGS3T is localized to the nucleus and induces apoptosis” J Biol Chem 275(28):21317-23 (2000) Labudova O, Cairns N, Koeck T, Kitzmueller E, Rink H, Lubec G - “Thyroid stimulating hormone-receptor overexpression in brain of patients with Down Syndrome and Alzheimer’s disease” Life Sci 64 (12):1037-44 (1999) http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10210286&form=6&db=m&Dopt=r Margolis RL, Chuang DM, Post RM - "Programmed cell death: implications for neuropsychiatric disorders" Biol Psychiatry 35(12):946-56 (1994) http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8080894&form=6&db=m&Dopt=r
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