CHROMOSOME X

   Several authors have found an association with Chromosome X and infantile autism (Cohen et al, 1991; Petit et al,1996).

   All subjects with fagile-X exhibited a blunted TSH response to thyrotropin releasing hormone (TRH) showing presence of subtle dysfunction within the hypothalamic-pituitary-thyroid axis.

   Elevated baseline prolactin levels were also observed among the fragile-X subjects (Bregman et al, 1990).

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Bregman JD, Leckman JF, Ort SI - "Thyroid function in fragile-X syndrome males" Yale J Biol Med 63(4):293-9 (1990) http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2125773&form=6&db=m&Dopt=r

Cohen IL, Sudhalter V, Pfadt A, Jenkins EC, Brown WT, Vietze PM - "Why are autism and the fragile-X syndrome associated?" Am J Hum Genet 48(2):195-202 (1991) http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&uid=1990832&Dopt=r

Petit E, Herault J, Raynaud M, Cherpi C, Perrot A, Barthelemy C, Lelord G, Muh JP - "X chromosome and infantile autism" Biol Psychiatry 40(6):457-64 (1996) http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8879465&form=6&db=m&Dopt=r